姓名：曹昊

性别：男

籍贯：辽宁丹东

联系电话：13022410815

E-Mail：caohao2008@163.com

个人主页：

职称/职务：副教授

通讯地址：辽宁省沈阳市沈河区文化路103号沈阳药科大学

邮政编码：110016

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学习/工作经历：

2014.8-至今 沈阳药科大学 生命科学与生物制药学院 讲师

2017.9-2019-9 清华大学 医学院 博士后

2008.8-2013.12 吉林大学 生命科学学院 博士

2004.9-2008.6 重庆邮电大学 生物信息学院 学士

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研究方向：

蛋白质的结构与功能

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兼职情况：

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科研/获奖情况：

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教学/指导研究生情况：

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发表论文/出版著作：

（1）Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulationof RSK2 protein signaling. J Biol Chem. 2013 Mar 1; 288(9):6259-71.（co-first author）

（2）TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone. Oncotarget. 2017 Jun 27;8(33):54966-54977.（co-first author）

（3）Trp358 is a key residue for the multiple catalytic activities of multifunctional amylase OPMA-N from Bacillus sp. ZW2531-1. Appl Microbiol Biotechnol. 2014 Mar;98(5):2101-11. （first author）

（4）Module recombination and functional integration of oligosaccharide-producing multifunctional amylase. Journal of Molecular Catalysis B: Enzymatic，2016.11.1，133：196~202 ; （first author）

（5）The second conserved motif in bacterial laccase regulates catalysis and robustnessJin Lanna; Yang Xue; Sheng Yongjie;Cao Hao; Ni Aixin; Zhang Yingjiu(*)Applied Microbiology and Biotechnology, 2018.5, 102(9): 4039~4048 ;

（6）The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk.Zhang Y, Zhao J, Yin M, Cai Y, Liu S, Wang Y, Zhang X,Cao H,Chen T, Huang P, Mai H, Liu Z, Tao H, Zhao B, Cui L.Oncotarget. 2017 Aug 16;8(42):72714-72726.

（7）A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer's Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis.Cui L, Cai Y, Cheng W, Liu G, Zhao J,Cao H, Tao H, Wang Y, Yin M, Liu T, Liu Y, Huang P, Liu Z, Li K, Zhao B.Mol Neurobiol. 2017 Apr;54(3):1939-1952.

（8）Ferulic acid inhibits the transition of amyloid-β42 monomers to oligomers but accelerates the transition from oligomers to fibrils.Cui L, Zhang Y,Cao H, Wang Y, Teng T, Ma G, Li Y, Li K, Zhang Y.J Alzheimers Dis. 2013;37(1):19-28

（9）Functional characterization of a special thermophilic multifunctional amylase OPMA-N and its N-terminal domain.Li F, Zhu X, Li Y,Cao H, Zhang Y.

Acta Biochim Biophys Sin (Shanghai). 2011 Apr;43(4):324-34.

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其他：

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