姓名：臧凌鹤
性别：女
籍贯：辽宁省沈阳
联系电话：18341401186、13555829345
E-Mail：linghezang@sina.com
个人主页：
职称/职务：副教授
通讯地址：沈阳市沈河区文化路103号
邮政编码：110016
学习/工作经历：
2009/09 - 2012/06，沈阳药科大学，药理学，博士，导师：池岛乔
2007/09 - 2009/06，沈阳药科大学，药理学，硕士，导师：徐峰
2003/09 - 2007/06，沈阳药科大学，药物制剂，学士
2012/08 -至今， 沈阳药科大学，生命科学与生物制药学院，讲师
2014/10 - 2015/03，日本武库川女子大学，药学部，访问学者
研究方向：
体内外细胞及动物实验模型，进行天然药物抗肿瘤活性筛选及分子机制研究；肿瘤免疫及微环境探索等。新药药理药效学及机制研究等。
兼职情况：
科研/获奖情况：
华会明，刘伟伟，臧凌鹤，李达竑. Novel enmein-type diterpenoidhybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. 沈阳市自然科技学术成果三等奖，2018.
臧凌鹤. “Oridonin purifiered from Chinese medical herb, Donglingcao, induced nitric oxide generation to promote the efferocytosis of apoptotic cells by hunman histocytic lymphoma U937 cells”, 中医药学会联合会, 优秀论文奖, 优秀奖, 2012.
教学/指导研究生情况：
承担本科生人体解剖学、人体解剖生理学理论及实验教学工作；指导本科生毕业专题、大学生创新创业项目
发表论文/出版著作：
（1）Zang L., Wang J., Ren Y., Liu W., Yu Y., Zhao S., Otkur W., Zhao Y., Hayashi T., Tashiro SI., Onodera S., Ikejima T. Activated toll-like receptor 4 is involved in oridonin-induced phagocytosis via promotion of migration and autophagy-lysosome pathway in RAW264.7 macrophages.Int Immunopharmacol, 2018,11(66): 99-108. IF:3.188
（2）Zang L., He H., Xu Q., Yu Y., Zheng N., Liu W.,Hayashi T., Tashiro S., Onodera S., Ikejima T.*.Reactive oxygen species H2O2and •OH, but not O2•(-)promoteoridonin-induced phagocytosis of apoptotic cells by humanhistocyticlymphoma U937 cells.Int Immunopharmacol, 2013, 15(2): 414-423. IF:2.23
（3）Zang L., Xu Q., Ye Y., Li X., Liu Y.,Tashiro S., Onodera S., Ikejima T.*.Autophagy enhanced phagocytosis of apoptotic cells byoridonin-treated humanhistocyticlymphoma U937 cells.Arch Biochem Biophys, 2012, 518(1): 31-41. IF:3.78
（4）Zang L., He H., Ye Y., Liu W., Fan S.,Tashiro S., Onodera S., Ikejima T.*.Nitric oxide augmentsoridonin-inducedefferocytosisby humanhistocyticlymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway.Free Radic Res, 2012, 46(10): 1207-1219. IF:2.67
（5）He H.,Zang L.,Feng Y., Wang J., Liu W., Chen L., Kang N., Tashiro S., Onodera S., Qiu F.*, Ikejima T.*. Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells.J Nat Prod, 2013, 76(5): 880-888. IF:3.88
（6）He H.,Zang L.,Feng Y., Chen L., Kang N., Tashiro S., Onodera S., Qiu F.*, Ikejima T.*. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-kappa B survival pathway in A375-S2 cells.J Ethnopharmacol, 2013, 148(2): 544-555. IF:3.11
（7）Liu W., Otkur W., Li L., Wang Q., He H.,Zang L.,Hayashi T., Tashiro S., Onodera S., Xia M.*, Ikejima T.*. Interference of silibinin with IGF-1R signalling pathways protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis.Biochem Biophys Res Commun, 2013, 432(2): 314-319. IF:2.55
（8）Liu W., Otkur W., Zhang Y., Li Q., Ye Y.,Zang L.,He H., Hayashi T., Tashiro S., Onodera S., Ikejima T.*. Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy.FEBS J, 2013, 280(18): 4572-4584. IF:4.53
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